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One possible explanation for the drop in GLP-1 in obese people is an increase in plasma non-esterified fatty acids (NEFA), according to Ranganath [115] et al

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doi: 10.1016/S2213-8587(23)00356-X [DOI] [PubMed] [Google Scholar] 81

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Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells