glp-1 from china approves first home-grown weight loss drug, rivaling Ozempic | Yanzhong Huang posted on the topic China GLP-1 Receptor Agonist Market

After years of trying to manage weight or blood sugar with limited success, it can feel exciting to begin a new chapter

Note: Rejections calculated among new patients within each brands first 12 months post-launch

However, "stronger" also means stronger side effects, with discontinuation rates of 12-18% for retatrutide versus 5-7% for semaglutide

These pathways have been conserved in humans and some primate mammals, functioning both in the CNS and peripheral nervous system

The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE(-/-) and LDLr(-/-) mice by a mechanism that includes inflammatory pathways

However, there are still major uncertainties regarding the reasons that limit the use of GLP-1 RAs, or what could be done to close the gap with guideline recommendations