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Clinical Trial Data: STEP-1 Study Results The STEP-1 (Semaglutide Treatment Effect in People with Obesity) trial remains the gold standard for understanding semaglutide weight loss results

D for preclinical only, case reports, or failed endpoints

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Clinical data shows that while GLP-1 medications do increase the risk of lean mass loss during aggressive calorie reduction, this outcome is not automatic and can be significantly minimized with proper planning

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