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Description
Similar to K cells, L cells also express the Galinin receptor, GAL 1 , and its activation via Galinin treatment or GAL 1 agonist (M617) treatment prevents the accumulation of cyclic adenosine monophosphate (cAMP) in L cells within primary duodenal cultures in response to the adenylyl cyclase activator, forskolin and inhibits GLP-1 secretion from primary duodenal and ileal cultures (Psichas et al., 2016)

Leki GLP-1 takie jak semaglutyd (Ozempic, Wegovy) czy tirzepatyd (Mounjaro) miay pomaga leczy cukrzyc

Aliment Pharmacol Ther 2012;35:10881096

How Mounjaro works Mounjaro mimics two hormones: Like Ozempic, it activates the GLP-1 receptor It also activates a second receptor called GIP (glucose-dependent insulinotropic polypeptide) This dual-action mechanism likely explains why Mounjaro produces greater weight loss and improvements in blood sugar in clinical trials

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Ble-Castillo, J
