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Wegovy (semaglutide 2.4 mg) approved in the US for the treatment of MASH Novo Nordisk Novo Nordisk announced that the FDA has approved an additional indication for Wegovy (semaglutide 2.4 mg) based on a supplemental New Drug Application (sNDA) for treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis), in combination with a reduced calorie diet and increased physical activity

Hypertension, elevated triglycerides, and prediabetes also qualify as conditions where weight management directly impacts treatment outcomes and medication burden

It is well established that activation of GLP-1R in pancreatic beta cells results in glucose-dependent potentiation of insulin secretion and a subsequent decrease of the blood-glucose level 2

PMID 2429796

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High Out-of-Pocket Cost and Insurance Barriers Brand-name Ozempic typically costs between $900 and $1,350 per monthly injection without insurance coverage