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Dehydration is a realistic concern because reduced appetite naturally leads to lower fluid intake

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A period of observation and treatment for these symptoms may be necessary, taking into account the half-life of tirzepatide of approximately 5 days

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SURMOUNT-3 was a multi-centre, randomised, double-blind, parallel, placebo-controlled trial comparing the efficacy and safety of tirzepatide to placebo for 72 weeks after a 12-week intensive lifestyle intervention lead-in period in adults with obesity or overweight with weight-related comorbidities, excluding type 2 diabetes

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