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Researchers affiliated with a European weight management company also recently reported that slowly tapering off the medications may help maintain weight loss

Oct 2002;56(8):365-79

Unlabeled Use Disclosure: Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA

There have also been documented local skin reactions when using GLP-1 RAs, particularly with the long-acting formulations

Retatrutide, a triple GLP-1/GIP/glucagon receptor agonist, is studied in metabolic research

Similarly, the 2020 guidelines of the American Association of Clinical Endocrinologists 44 recommend long-acting GLP-1 receptor agonists or SGLT-2 inhibitors in patients with type 2 diabetes and established or high risk of atherosclerotic cardiovascular disease with or without chronic kidney disease, regardless of glycemic control