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GLP-1 is related to BP which depends on species, administration methods and physiological conditions
DOI:10.1016/j.tcm.2021.12.008 3

semaglutide in obesity An analysis in Diabetes, Obesity and Metabolism suggest that the cost per 1% of body weight reduction is lower for tirzepatide than semaglutide

What the SURMOUNT data shows The SURMOUNT-1 trial at the 36-week mark shows average weight loss of approximately 15 to 17 percent of body weight on the 10 mg and 15 mg doses

As of April 2026, retatrutide is not approved by the FDA, is not approved by the EMA, and has no active approval in any major regulatory jurisdiction

However, glycaemic control may worsen within 1 to 2 weeks, potentially causing hyperglycaemia symptoms such as increased thirst, frequent urination, and fatigue if alternative diabetes medication is not initiated
