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This rapid degradation is the primary reason that GLP-1 receptor agonist drugs require structural modifications such as DPP-4 resistance mutations, albumin binding, or Fc fusion to achieve a pharmacologically useful duration of action

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As supply catches up with demand and approvals widen their reach to new disease areas, these remarkable drugs stand poised to reshape healthcare, delivering a healthier future for individuals struggling with obesity and its devastating consequences.

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Mentlein, R

Garre-Olmo, O