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Gastrointestinal adverse events, including nausea, were consistently the most common side effects reported across all dose groups

CHAKRABARTI: So, yes, it's problematic, but it's a decision that was also made

the trial set 2mg as the lowest active arm, not as an absolute minimum starting point

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However, despite their significant quality of life improvements, they can be accompanied by significant gastrointestinal side effects, including nausea, vomiting, abdominal pain, diarrhea, fatigue, and weight loss 16