what is glp-1 vs. GLP-1 + GIP: What's the Difference for your Metabolism? GLP-1 Medications for Weight Loss:

2023;doi:10.1056/NEJM0a2302392

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While patients in the study achieved meaningful weight loss, individual results varied: The research group earlier documented two primary drivers that contributed to patients stopping their medication: cost or insurance coverage limitations and side effects, with the former being the dominant reason

The primary concern is the combined glucose-lowering effects of these drugs

Taken together, a growing body of literature suggests that GLP-1RAinduced feeding suppression and weight loss are mediated by multiple GLP-1Rexpressing CNS populations and their downstream targets

Obesity is also strongly associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis, which is inflammation-driven [25,26,27]