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Introduction Brief history of metformin The insulin-response sensitizer metformin ( N , N -dimethylbiguanide) has been an important drug for the treatment of diabetes since the 1950's, being one of the most widely prescribed anti-hyperglycemic compounds

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Colorectal Cancer CRC ranks among the most prevalent malignant tumors globally, with its development involving a multifactorial, multistage process [127]

The pathways include inflammation, vascular damage, mitochondrial dysfunction, the effects of insulin resistance (IR) on metabolism in the brain, the formation of advanced glycation end products (AGEs), and the aggregation of pathological proteins such as A and -synuclein [12]