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After 40 weeks, people taking retatrutide had average HbA1c reductions of around 1.7 to 1.9 percentage points

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Clinical trials have demonstrated that semaglutide can facilitate an average weight loss of 15 to 20 percent when paired with lifestyle changes, ranking it among the best weight loss medications available

If oral semaglutide 14 mg is used for 14% of these patients (279 of 1993 patients on sitagliptin 100 mg), as presented in the Institute for Clinical and Economic Review report from their threshold analysis, the 5-year direct healthcare cost rises to $US51,319,140, an incremental cost increase of 9.9% ($US4,620,201, or $US0.08 per member per month [PMPM]) (Fig