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Delayed gastric emptying may undergo tachyphylaxis, potentially reducing the impact of DDIs with repeated dosing.169,174 Moreover, delayed absorption of the concomitant drug due to delayed gastric emptying can be minimized by administering the drug 1 h before GLP-1 RAs or a dual GLP-1/GIP RA administration.168 However, the possibility of DDIs related to delayed gastric emptying cannot be excluded,175 so investigators recommend monitoring when oral drugs are co-administered with GLP-1 RAs and a dual GLP-1/GIP RA

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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Gurkan E, Tarkun I, Sahin T, Cetinarslan B, Canturk Z

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Both patients began experiencing resolution of their symptoms within 1 month of discontinuing semaglutide

The fiber sits in your digestive tract, absorbing whatever moisture is available, potentially creating a dense, hard mass that worsens constipation significantly