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The impact has been vast and further preclinical studies are still necessary to explore and understand the potential of the drugs that have already revolutionised the lives of millions of people with obesity and type 2 diabetes
This mechanism further supports the role of GLP-1RAs in blood pressure regulation and nephroprotection [87]
The most frequent are gastrointestinal issues like nausea, vomiting, or constipation
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During the mean observation period of 3.3 years, semaglutide at 2.4 mg per week resulted in a mean weight loss of 9.39% from baseline and a 20% reduction in the risk of MACE (HR 0.80, 95% CI 0.720.90), especially a 28% reduction in the risk of myocardial infarction (HR 0.72, 95% CI 0.610.85), compared with that in the placebo group
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