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(2016) demonstrated that blocking estrogen receptor signaling abolished the suppressive effects of GLP-1R activation on reward-related behavior, further supporting the idea that estrogen is a critical modulator of GLP-1s central effects on motivated responding

Further randomized controlled trials and long-term observational studies are needed to validate its efficacy and safety profile

In subjects with a higher baseline BMI (above 40 kg/m), the percentage body weight reduction observed at each retatrutide dose may translate to a larger absolute kilogram loss

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A few simple steps can help them further improve their ocular health and manage DED symptoms