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In the fasting state, AG is elevated (~110 pM) and decreases (~70 pM) in response to food ingestion

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Conceio EM, Mitchell JE, Machado PPP, Vaz AR, Pinto-Bastos A, Ramalho S, et al

In these trails, GLP-1RAs exerted renoprotection, irrespective of the baseline HbA1c (Kristensen et al., 2019)

[16] [17] These studies, involving tens of thousands of patients, have found no significant association between GLP-1 receptor agonist use and increased cancer incidence overall, including breast cancer specifically

These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight