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The definition of the disproportionality approach can be found in Additional file 1: section 4 [29]

Also, GLP-1 RA seems to regulate glucose homeostasis by exhibiting glucagonostatic effects meaning suppression of glucagon by acting on pancreatic cells, which in turn reduce hepatic production of glucose (52)
The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update

GLP-1-ra and heart failure-related outcomes in patients with and without history of heart failure: an updated systematic review and meta-analysis
Furthermore, cardiovascular results for oral semaglutide were similar to the results observed in the SUSTAIN-6 trial with injectable semaglutide, suggesting that the oral and SC formulations share similar cardiovascular safety profiles

Another study indicates that starting treatment with a lower dose and gradually increasing it helped reduce the incidence of gastrointestinal adverse events [64]
