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Moreover, administration of exendin-4 led to a reduction in 5-HT and 5-HIAA, whereas GLP-1R antagonists increased the levels of serotonin and its metabolites [56]

GLP-1 suppresses feeding behaviors and modulates neuronal electrophysiological properties in multiple brain regions

Exenatide is anticipated to register 35.4% of the market share in 2024

Furthermore, GLP-1 receptor agonists protect against neurodegeneration by suppressing tau hyperphosphorylation

Conclusions In this large cohort study, the use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with the use of DPP-4 inhibitors or SGLT-2 inhibitors in patients with type 2 diabetes
