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An invited commentary on this study, also published in JAMA Ophthalmology, challenges the idea that the increased risk of NAION among semaglutide users resulted directly from the medication

The major difference is what they are FDA approved for

doi: 10.1038/ejcn.2013.90

Glucagon: Increases energy expenditure and promotes fat breakdown

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Very spicy foods can irritate an already-sensitive stomach lining
