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Retatrutide adds glucagon receptor agonism to the GLP-1 and GIP targets already covered by tirzepatide, which is hypothesised to further stimulate hepatic fatty acid oxidation and lipid clearance

Donna Ryan, MD, and other panelists reported on new data from phase 3 trials evaluating the combination of cagrilintide, which mimics amylin, and semaglutide, a glucagon-like peptide-1 receptor agonist, in adults

The proportion of cardiac catheterization patients with SGLT2 inhibitor prescriptions before the procedure showed modest but steady growth, increasing from 0.5% in 2018 to 1.6% in 2023 (Figure 4)

Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure

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The overall side effect profiles are similar , both are mostly stomach-related