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Journal of Endocrinology 179 , 447454, doi:10.1677/joe.0.1790447 (2003)

Metformin is an older insulin-sensitizing drug developed in the 1950s, while GLP-1 agonists like semaglutide are newer hormonal therapies that activate specific intestinal receptors

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As a general guideline, Semaglutide GLP-1 injections are typically prescribed to individuals with a BMI of 30 or above or 27 and above with at least one weight-related condition, such as high cholesterol, osteoarthritis, or sleep apnea

Ex-enatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial
