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Studies have shown that antioxidants have a protective effect against type 2 diabetes development because they impede the formation of free radicals

Additionally, preclinical research suggests GLP-1 agonists may inhibit nuclear factor-kappa B (NF-B) signaling, a central pathway in inflammatory responses

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In the Italian cohort, at baseline, the most common glucose-lowering treatment was metformin (79.9%) [36], which was similar to PIONEER REAL Netherlands (81.3%)

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