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Constitutive hGPR17L activity inhibited GLP-1 secretion, and MDL29,951 treatment further inhibited this secretion, which was attenuated by treatment with the GPR17 antagonist HAMI3379

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GLP-1 medications such as Ozempic and Wegovy have significantly reshaped the weight loss market by improving blood sugar regulation, insulin sensitivity, and appetite control

Acquired conditions and genetic factors have been implicated in IR
