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Berberine does have published research behind its effects on blood glucose and insulin sensitivity in specific study populations

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liver or kidney problems

More recent analyses suggest that spexins metabolic actions may be dissociable from its nociceptive or affective effects through receptor subtype selectivity and dosing strategies (Kim et al., 2014)

If your urine is consistently light yellow to clear, you are probably adequately hydrated

The concern is purely mechanicalrelated to absorption rather than metabolism
