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Owing to the increasing popularity of GLP-1 receptor agonists and the inconsistency of observational studies on this potential association, we did a large, observational study to estimate the average treatment effect of continuous GLP-1 receptor agonist use compared with continuous dipeptidyl peptidase-4 (DPP-4) inhibitor or sodium-glucose cotransporter-2 (SGLT-2) inhibitor use on suicidal ideation, self-harm, and suicide among patients with type 2 diabetes