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These genetic differences explain why some people are hyperresponders who feel appetite suppression from the very first dose, while others require several weeks of dose escalation before noticing meaningful changes

By doing so, they stimulate the release of insulin from the pancreas, which helps lower blood sugar levels

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Reduced counterregulation could be linked to recurrent but unrecognized hypoglycaemia, changes in glucose sensing, or hormonal and metabolite signalling in the CNS

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