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Skip it and you risk contaminating a vial worth hundreds of dollars

No, priming instructions remain the same
A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) - Full Text View - ClinicalTrials.gov (n.d.)

7 A major challenge in the management of obesity is the prevention of a return to pathologically high levels of weight and adiposity after initial success in weight loss and body re-composition

Weight Loss Tirzepatide is sold under the name Zepbound

Pregnancy Tirzepatide is not recommended during pregnancy
