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Additionally, incretin therapies can have overbearing negative side effects including hypoglycaemia (often in combination with other glucose-lowering treatments), nausea, vomiting, gastrointestinal upset (including diarrhoea) and injection site reactions that contribute to therapy discontinuation (Trujillo et al., 2021)

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When used with insulin or sulfonylureas, these medications may increase hypoglycemia risk, requiring dose adjustments of those agents

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Exposure to air or humidity can reduce adhesive and nutrient stability

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Crosstalk between gut microbiota and antidiabetic drug action

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