why does semaglutide make me so tired you sleepy Replying to @Hatithef fatigue with glp1 meds #semaglutide #tirzepatide Does Semaglutide Make You Sleepy?

Given the investigational nature of both peptides, particularly their combination, careful consideration of sourcing, administration, and monitoring is essential for responsible and ethical research

It is worth noting that, consistent with experience across the GLP-1/GIP class, weight loss in people with type 2 diabetes may be somewhat smaller in magnitude compared with those with obesity alone

Dosing starts low and increases gradually to minimize side effects

these medications may need dose adjustment Increased heart rate, typically a modest elevation Dehydration risk, especially with persistent vomiting or poor fluid intake, which can lead to acute kidney injury According to MHRA guidance, rare but serious adverse effects include acute pancreatitis (inflammation of the pancreas), gallbladder disease including cholelithiasis (gallstones), and thyroid C-cell tumours (observed in rodent studies

It was also demonstrated that treatment with semaglutide compared with placebo resulted in reduction in new-onset macroalbuminuria by 46%

JAMA Netw Open 7(1):e2350408e2350408 [DOI] [PMC free article] [PubMed] [Google Scholar] Deacon CF (2019) Physiology and pharmacology of DPP-4 in glucose homeostasis and the treatment of type 2 diabetes