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Front Endocrinol (Lausanne) 2022;13:863592.PubMedPMC 43

After a follow-up of 27 months, the researchers reported that just over half of patients (54%) discontinued their prescription for at least 135 days

Yesthe PlexusDx Precision Peptide Genetic Test examines variants like GLP1R rs6923761 and GIPR rs1800437 to predict whether you'll respond robustly to semaglutide alone or whether dual-action tirzepatide might enhance food noise reduction

Umbareen Mahmood, MD, a board-certified plastic surgeon in New York City, says shes now even encountering men and women with already-low BMIs who are using the drugs to lose a few pounds for a big event or beach vacation. Surprisingly, many of these patients are still seeing negative aesthetic side effects, likely due to how rapid the weight loss wasthose who lose weight gradually tend to have better tissue elasticity and skin retractionand also because their margin for loss is smaller given that they were already at a healthy weight for their body. (When someones BMI is low to start, she explains, losing a few pounds can have a significant impact on the little bit of fat you have.) Jerry Chidester, MD, a board-certified plastic surgeon in Draper, Utah, tells me that close to half of his patients are currently using a GLP-1 or have in the past

Digital twin models also require accurate parameters (fluid dynamics, reaction kinetics) that must be calibrated from real-world experiments

It is meant to work with lifestyle changes, not replace them