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Both glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors can reduce CV risk in patients with T2D, and both are recommended by the American Diabetes Association to reduce the risk of major cardiovascular events (MACE)

However, there may be unappreciated benefits of this combination of therapies

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Tirzepatide, the first dual GIP/GLP-1 receptor co-agonist approved for type 2 diabetes in the USA, Europe, and the UAE, targets both appetite and glucose control