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Diamant M, Van Gaal L, Guerci B, et al

I 2 = 24%)

Following the withdrawal of albiglutide from the market in 2018 by the manufacturer for financial reasons (257), liraglutide, injectable semaglutide, and dulaglutide should currently be the preferred choices within this class for reducing cardiovascular events until further data are available (248)

doi: 10.1139/o71-122

Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia

34 , 35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36 , 37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38 , 39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals