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References Coskun, T., Sloop, K.W., Loghin, C., Alsina-Fernandez, J., Urva, S., Bokvist, K.B., Cui, X., Briere, D.A., Cabrera, O., Roell, W.C., Kuchibhotla, U., Moyers, J.S., Benson, C.T., Gimeno, R.E., DAlessio, D.A., & Haupt, A
Furthermore, the inhibition of GLP-1 secretion with MDL29,951 was concentration-dependent and was attenuated by the small molecule GPR17 nonselective antagonist HAMI3379
& Lacroix, A

Importantly, tirzepatide shows preferential potency at GIPR relative to GLP-1R, which is one reason its metabolic effect profile differs from GLP-1 mono-agonists such as semaglutide

Like millions of Americans, Luker-Stewart went on a GLP-1 weight-loss drug and watched 60 pounds quickly melt away

Plus there are some who have made the decision to take GLP-1 for life
