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Consuming carbohydrates, proteins, and fats causes the release of GLP-1 into the bloodstream

However, the risk of aspiration due to delayed gastric emptying has raised concern regarding the safety of GLP-1 agonists in the perioperative setting : The ANZCA Safety and Quality Committee recently presented two case reports of gastric contents identified on elective gastroscopy in patients using GLP-1 agonists despite adequate fasting times

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Several GLP-1 and dual GIP/GLP-1 receptor agonists have been developed to harness these pharmacological effects in the treatment of type 2 diabetes, with some demonstrating robust effectiveness in weight management and prevention of cardiovascular diseases