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This much-needed programme will offer URGENT help to address the issues seen in general practice as a result of the national shortage of GLP-1 Receptor Agonists

Methods We administered male rats with intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) GLP-1R agonist (exendin-4) or antagonist (exendin-9-39) followed by in vivo determination of CSF dynamics

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Explore clinically appropriate ways to address cost-driven pressures for GLP-1s.

Furthermore, AMPK inhibitor compound C abolished the metformin-mediated upregulation of GLP-1R level and PKA phosphorylation