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46 GIPR is expressed in monocytes that infiltrate vessel walls and differentiate into macrophages and form cells as a component of the atherosclerosis plaque

Tirzepatide also showed improvements in lipids and cardiovascular risk factors compared to dulaglutide 1.5 mg and placebo

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Hirata Y, Kurobe H, Nishio C, Tanaka K, Fukuda D, Uematsu E, Nishimoto S, Soeki T, Harada N, Sakaue H

Blood sugar management at the starting dose is generally favorable, but coordination with a healthcare provider who manages diabetes medications is important to prevent hypoglycemic events as retatrutide begins improving insulin sensitivity

Dosages varied among studies, with most participants starting at a minimum dose that was gradually increased weekly