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Gout rates were also slightly higher, with 7 percent of GLP-1 users developing the condition, putting them at nearly a 12 percent higher risk than those who did not use the medications

On April 30, 2026, the FDA took the more sweeping step of proposing to permanently exclude semaglutide, tirzepatide and liraglutide from the 503B Bulks List the list of ingredients that large-scale compounding facilities are legally permitted to use

This impaired contractility contributes to bile stasis, a situation in which bile remains in the gallbladder for prolonged periods, increasing the likelihood of cholesterol crystallization and gallstone formation