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The World Health Organisation's 2026 global guidelines on GLP-1 therapies for obesity explicitly recommend combining medication with intensive behavioural interventions, including structured goal-setting for diet and physical activity

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GLP-1GIPlanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPAR, PPAR and PPAR, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin and PPAR activity.