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Individual responses to GLP-1RA could be influenced by specific genotypes, for example, individuals with the Taq1A dopamine receptor 2 polymorphism exhibit decreased binding to dopamine [157]

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These results are consistent with previous reports in which GLP-1 and GLP-1R agonists cause transient increases in MAP and HR in both normotensive and hypertensive rodents [10, 13, 17, 57, 58]

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