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moderate-certainty evidence), and 36 months (MD 4.10, 95% CI 1.40 to 6.79

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Both medications target blood sugar control through different mechanisms, making combination therapy a viable option for many people seeking comprehensive metabolic support

Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures

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Available in low dose (3 mg) and high dose (9 mg) protocols