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and secondary stimulation (associated with activation in neighbouring areas, rather than influence on GLP-1Rs) of C-Fos neurons in the thalamic nuclei and CGRP neurons in the parabrachial nuclei

This effect was paralleled with increases in sAC activity, as measured by cAMP accumulation in the same lysates (Figure 4B)

Thomson, A

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Genetic evidence showed that GLP-1 RAs were likely associated with reduced risks of anxiety, depression, emotional lability, bipolar disorder, and suicide

10,23,24 Similarly, there was no increased risk of pancreatic cancer associated with GLP-1RAs in a large cohort study and a 2020 meta-analysis