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These pleiotropic effects, largely mediated through enhanced insulin sensitivity, anti-inflammatory pathways, and metabolic regulation, position tirzepatide as a promising agent in the integrated management of chronic metabolic diseases

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Many companies aside from Lilly and Novo Nordisk are also jumping on the train, testing their own GLP-1s in clinical trials, which could help with shortages in the future

Supplementary information Acknowledgements We acknowledge the contributions of the clinical staff of the Intramural Research Program of the National Institute on Drug Abuse, and the Clinical Research Unit of Johns Hopkins Bayview Medical Center, as well as the University of Maryland, Baltimore, a member of the Graduate Partnership Program, National Institutes of Health (NIH)