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Ethics statement Animals were studied and maintained in accordance with the Institutional Animal Care and Use Committee of Eli Lilly and Company and the Guide for the Use and Care of Laboratory Animals by the National Institutes of Health

Significant improvement over single agonist but still lacks the energy expenditure component

GLP-1 does several things in the body, but one of its primary purposes is to regulate the body's ability to convert excess nutrients into stored fat, as well as the signals the body sends to the brain to tell it when you're hungry

GLP-1 plays several critical roles in glucose and appetite regulation: it stimulates insulin release from the pancreas, inhibits glucagon secretion to prevent excess glucose production, slows gastric emptying to moderate post-meal blood sugar spikes, and promotes satiety by acting on hunger centers in the brain (6)(23)

So, if you only care about living longer, might the benefits of weight loss outweigh the risks of dying on the operating table

Now, whispers in research labs are about triple agonists, single injections that stimulate GLP-1, GIP, and glucagon receptors all at once