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BMJ Open 9(5):e024065
However, post hoc and pooled analyses of clinical studies investigating semaglutide in both obesity and T2D have shown that GI AEssuch as nausea, vomiting, and diarrhoeacontribute minimally to overall weight reduction
Additionally, significant changes were noted in the composition of the bone matrix of these animals, with decreased enzymatic cross-linking of the collagenous matrix, which clearly worsened the compromised biomechanical strength and contributed to the observed bone fragility [44]

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Furthermore, long-term studies focusing on safety, efficacy, and patient-specific factors will be essential to translate these innovations into viable therapeutic options

Zepbound may be an effective option for individuals who have struggled with obesity or excess weight despite lifestyle efforts
