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For SURMOUNT4, participants were to have reached their MTD dose by week 24, have no dose reduction by week 88, and have a weight measurement at week 88

At 88 weeks, the tirzepatide group achieved an additional 5.5% weight loss, whereas the placebo group had a weight regain of 14%

They may only affect pills and only at starting and dosage increases, but the data are sparse

Does everyone need to reach 15 mg

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The psychological relief is significant