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Reminder

There are two primary ways healthcare professionals handle this transition: the Washout method and the Direct Switch method

It is known that acute, but not chronic, central GLP-1 receptor activation directly modulates glucose-induced Insulin secretion implicating a direct brain to islet neuronal communication ( On the other hand, chronic GLP-1 activity in -cells increases its own secretion, feeding an autocrine loop that gets overstimulated with the use of exogenous synthetic GLP-1R agonists [(2]

Moreover, semaglutide decreased seizure severity, alleviated hippocampal neuronal apoptosis, ameliorated cognitive dysfunction, blocked NLRP3 inflammasome activation and decreased inflammatory cytokine secretion in PTZ-kindled mice

For patients with significant risk factorssuch as those experiencing gastrointestinal side effects, those in the dose-escalation phase, or those with known gastroparesisadditional precautions may be considered

Based on the STEP-1 phase-3 program