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While acknowledging that GLP-1 agonists have revolutionized the way diabetes and obesity are managed and play an important role in the care of many patients, the commentors ask, Will healthcare professionals prescribe these medications because they lead to a decreased risk of AMD

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These longer-acting GLP-1R mimetics elicit more favourable cardiovascular outcomes than shorter-acting agents like exenatide or its analogue lixisenatide (EXSCEL and ELIXA), which demonstrated non-inferiority, but no obvious cardiovascular benefit [(64, 119, 148)

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Understanding the mechanisms behind this effect is essential for clinicians and patients alike