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A significant decrease in the mRNA expression of antioxidant enzyme genes such as Sod1, Sod2, Cat, and Nrf2 was observed in the positive control group and followed by a gradual and significant increase in GS-treatment groups (Figure 6C and Figure 7B,C)

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It is important to note that adipose tissue biology exhibits significant sex dimorphism, with well-described sex- and depot-specific differences in adipose tissue cellular composition, endocrine function, and inflammatory regulation [73]

While it offers potential advantages such as fewer side effects, lower costs, and better adherence, the practice still requires more research to confirm its safety and effectiveness