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The results of RT-qPCR indicated that GLP-1RAs downregulated the expression of IL-6 , TNF- , and iNOS , and upregulated the expression of IL-10 , TGF- , and Arg-1 (Fig

Inhibition of dipeptidyl peptidase IV activity by oral metformin in type 2 diabetes

Due to the evident decline in the insulinotropic impact of GIP on individuals with T2DM (potentially attributed to the desensitization of the GIP system) (Vilsbll et al., 2003), the focus of GIP research has shifted from glucose homeostasis to other areas, such as bone metabolism and other diseases

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